Nanostructured formulations for delivery of silibinin and other active ingredients for treatment of ocular diseases

• Main Authors: CAVALLARO GENNARA, PAPASERGI SALVATORE, SALADINO PATRIZIA, DEIDDA IRENE, BLANCO ANNA RITA, CRAPARO EMANUELA FABIOLA, BONDI MARIA LUISA, GIAMMONA GAETANO, LA MARCA CLARA, ESPOSITO EMANUELA, VIOLA SANTA, GUARNERI PATRIZIA, LICCIARDI MARIANO, GRANATA GIUSEPPE, PITARRESI GIOVANNA, CUZZOCREA SALVATORE, CONSOLI GRAZIA MARIA LETIZIA
• Format: Patent
• Language: Chinese; English
• Published: 04.12.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present application relates to nanostructured formulations for the delivery of silibinin and other active ingredients for the treatment of ocular diseases. Formulations comprising silybin or otheractive ingredient incorporated into SLN and NLC type lipid nanoparticle systems, and calixarene-based (possibly mucoadhesive) incorporated or incorporated into micelles and nanoparticle systems in the form of amphiphilic inulin copolymers are described, which are useful in the treatment of neurodegenerative eye diseases. Also described are multifunctionalities of calixarene compounds that are capable of loading and releasing active ingredients to be used in the treatment of ocular diseases, characterized by low water solubility, ease of chemical and enzymatic degradation, low bioavailability,regardless of whether they are natural sources. 本申请涉及用于治疗眼部疾病的用于递送水飞蓟宾和其他活性成分的纳米结构化制剂。描述了包含被掺入到SLN和NLC型脂质纳米颗粒体系、以及基于杯芳烃(calixarene)(可能地粘膜粘附剂)掺入的或者掺入到呈基于两亲性菊粉共聚物的胶束和纳米颗粒体系中的水飞蓟宾(silibinin)或其他活性成分的制剂，所述制剂用于治疗神经变性眼部疾病。还描述了杯芳烃化合物