Synthesis method and application of prothioconazole
The invention relates to the technical field of chemical drug synthesis, and especially relates to a synthesis method and application of prothioconazole. The synthesis method of prothioconazole comprises the following steps: 1, carrying out an epoxidation reaction on a compound represented by formul...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
01.12.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to the technical field of chemical drug synthesis, and especially relates to a synthesis method and application of prothioconazole. The synthesis method of prothioconazole comprises the following steps: 1, carrying out an epoxidation reaction on a compound represented by formula IV to obtain a compound represented by formula III; 2, performing nucleophilic addition reaction on the compound of the formula III and triazole to obtain a compound represented by formula II; and 3, carrying out a vulcanization reaction on the compound of the formula II to obtain prothioconazolerepresented by formula I. The prothioconazole is prepared by taking the compound of the formula IV as an initial raw material through the epoxidation reaction, the nucleophilic addition reaction and the vulcanization reaction, so the cost is low, safety and high efficiency are achieved, potential safety hazards are avoided, the overall yield is high, reaction conditions are mild, the raw materialutilization rate is increa |
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Bibliography: | Application Number: CN202010988454 |