COMPOUNDS THAT MODULATES AMPA RECEPTOR FUNCTION

• Main Authors: PORTER RODERICK ALAN, VILLALONGA-BARBER CAROLINA, WARD SIMON, BESWICK PAUL, REUILLON TRISTAN, PENNICOTT LEWIS, CHUCKOWREE IRINA
• Format: Patent
• Language: Chinese; English
• Published: 27.11.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds of the formula (I): (I) wherein A1, A2, R2, R4, B1, B2, X, X1, n, a and b are as defined are defined in the specification, to pharmaceutical compositions comprising the compounds and the compounds for use as medicaments. The compounds potentiate AMPA receptor function and are expected to be useful in the treatment of central nervous system disorders, for example inthe treatment of depressive disorders, mood disorders and cognitive dysfunction associated with neuropsychiatric disorders such as schizophrenia. 本发明提供式(I)的化合物：(I)其中A1、A2、R2、R4、B1、B2、X、X1、n、a和b如说明书中所定义，涉及包含这些化合物的药物组合物，以及这些化合物用作药物。这些化合物增强AMPA受体功能，并且预期可用于治疗中枢神经系统障碍，例如治疗抑郁障碍、心境障碍和与神经精神病学障碍诸如精神分裂症相关联的认知功能障碍。