Application of pirfenidone to preparation of medicine for preventing and treating rheumatoid arthritis

• Main Authors: KE LIQING, ZHANG PENG, CHENG WENXIANG, GAN DONGHAO
• Format: Patent
• Language: Chinese; English
• Published: 27.11.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The application relates to the technical field of medicines, in particular to an application of pirfenidone to preparation of a medicine for preventing and treating rheumatoid arthritis and the medicine for preventing and treating rheumatoid arthritis. According to the application of the pirfenidone to preparation of the medicine for preventing and treating rheumatoid arthritis, the chemical structural formula of the pirfenidone is shown as a formula 1, or salt as shown in the formula 1. The pirfenidone can effectively restrain an RA process by restraining inflammatory reaction and restrainingkey pathologic links of vascular proliferation and the like, so that rise of inflammatory factors of interleukin 6, interleukin 8, interleukin 1 beta and the like secreted by human RA fibroblasts induced by tumor necrosis factors alpha can be notably reduced, abnormal rise of expression level of the vascular endothelial growth factors secreted by the human RA fibroblasts induced by tumor necrosisfactors alpha can be nota