Oral insulin intelligent nanorod and preparation method thereof

• Main Authors: TAN XING, XIONG DI, TENG WENQI, WU ZHIMIN, LIU YUEJIN
• Format: Patent
• Language: Chinese; English
• Published: 13.11.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention discloses an oral insulin intelligent nanorod and a preparation method thereof, and relates to the technical field of biological medicines. The intelligent nanorod is composed of an inner core layer, a middle layer and an outer shell layer, wherein the inner core layer is formed by mixing insulin and a small molecule permeability enhancer, the middle layer is made of a mesoporous silica rod-like material, and the outer shell layer is made of a pH-sensitive enteric coating material. The oral insulin intelligent nanorod has pH sensitivity, the encapsulation efficiency can reach 95percent or higher, and the drug loading capacity can reach 15 percent; the mesoporous silica and insulin show strong charge repulsive force when the pH value is greater than 6, so that release of insulin in intestinal juice can be promoted; meanwhile, a permeability enhancer can open an opening tightly connected with intestinal epithelial cells and can also cause reversible disturbance to cell membranes, so that the medic