Application of echinenone in preparation of acetylcholinesterase inhibitor

• Main Authors: XIAO ANFENG, ZHANG TAO, DU XIPING, LI ZHIPENG, JIANG ZEDONG, LI LIJUN, NI HUI, HUANG GAOLING, HU YANG, YANG YUANFAN, ZHANG YONGHUI, CHEN YANHONG
• Format: Patent
• Language: Chinese; English
• Published: 06.11.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to an application of echinenone in preparation of an acetylcholinesterase inhibitor. The echinenone has an obvious inhibition effect on acetylcholinesterase, regulates and controls the activity of AchE in a brain, and reduces the hydrolysis of acetylcholine in the brain, so that the acetylcholine level at a nervous system receptor in the body of a patient is improved, the hydrolysis speed of acetylcholine is delayed, and the Alzheimer's disease is effectively improved. 本发明涉及一种海胆酮在制备乙酰胆碱酯酶抑制中的应用。其中，海胆酮对乙酰胆碱酯酶具有明显的抑制作用，在大脑中调节及控制AchE的活性，减少其对脑内乙酰胆碱的水解，进而提高患者机体内神经系统受体处的乙酰胆碱水平，延缓乙酰胆碱的水解速度，从而有效改善老年痴呆症。