A MODIFIED BRUCELLA VACCINE STRAIN FOR THE TREATMENT OF BRUCELLOSIS

• Main Authors: SAN ROMAN ABERASTURI BEATRIZ, ZABALZA BARANGUA ANA, PALACIOS CHAVES LEYRE, GRILLO DOLSET MARIA JESUS, MENA BUENO SARA
• Format: Patent
• Language: Chinese; English
• Published: 30.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present application provides a modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The Brucella strain has been modified through an inactivation of the wzm gene. Further, the present application provides a pharmaceutical composition which comprises the modified Brucella strain, its use as a medicament, and its use as a medicament for the treatment and/or prevention of brucellosis. The present application also provides a kit which comprises the modified Brucella strain and a pharmaceutically acceptable carrier ordiluent and its use for the treatment and/or prevention of brucellosis. 本申请提供了经修饰的布鲁氏菌菌株、其作为药物的用途、及其作为用于治疗和/或预防布鲁氏菌病的药物的用途。已通过使wzm基因失活对布鲁氏菌菌株进行了修饰。此外，本申请提供了包含经修饰的布鲁氏菌菌株的药物组合物、该药物组合物作为药物的用途、以及该药物组合物作为用于治疗和/或预防布鲁氏菌病的药物的用途。本申请还提供了包含经修饰的布鲁氏菌菌株和药学上可接受的载体或稀释剂的试剂盒，以及其在治疗和/或预防布鲁氏菌病中的用途。