Method for detecting triethylamine in cefotaxime sodium and application of method

• Main Authors: FAN ZHAOZE, LIU SHAOQUN, LIU SONGLIN, WU ZHEN, YU YANPING, ZHANG LU, DUN WEI, GONG DANFENG, YANG ZIXIAN, XU YONG
• Format: Patent
• Language: Chinese; English
• Published: 30.10.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a method for detecting triethylamine in cefotaxime sodium and application of the method. According to the method for detecting triethylamine in cefotaxime sodium, gas chromatography detection is carried out in a headspace sample injection mode, and the chromatographic column is one of Agilent CP-Sil 8 CB with 30m * 0.32 mm and 1.0 micron or a chromatographic column with equivalent efficiency; the detection process comprises the following steps: injecting a triethylamine reference substance solution and a cefotaxime sodium test solution into a gas chromatograph in a headspace sample injection manner, and performing detecting according to an external standard method. According to the method for detecting residual triethylamine in cefotaxime sodium, to-be-detected triethylamine in cefotaxime sodium can be effectively separated, and the peak shape and the separation degree are good. 本发明公开了一种头孢噻肟钠中三乙胺的检测方法及其应用。本发明提供的一种头孢噻肟钠中三乙胺的检测方法，其采用以顶空进样的方式进行气相色谱法检测，其中，色谱柱：Agilent CP-Sil 8 CB，30m×0.32mm