Preparation method of cross-linked hyaluronic acid filling agent for injection

• Main Authors: PAN CUNCAI, LIU JIANJIAN, ZHANG YAN, GUO XUEPING, SU JIANGWEI, WU WANFU
• Format: Patent
• Language: Chinese; English
• Published: 30.10.2020
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention discloses a preparation method of a cross-linked hyaluronic acid filling agent for injection. The method comprises the following steps: preparing cross-linked hyaluronic acid microspheres by a low-temperature control reversed-phase emulsification cross-linking technique, uniformly mixing the cross-linked hyaluronic acid microspheres with hyaluronic acid gel, and drying to obtain thefilling agent. The microsphere has the characteristics of simple preparation steps, mild reaction conditions, less cross-linking agent dosage, good cross-linking uniformity, high safety and the like;the obtained filler contains non-crosslinked hyaluronic acid and crosslinked hyaluronic acid microspheres at the same time, can achieve the purposes of quickly filling pits and maintaining a long filling effect at the same time, can be quickly degraded by taking measures during excessive correction or misoperation, reduces the risk of product injection, and is suitable for being applied to the field of soft tissue filling.