Salt of aryl propionic acid compound, and pharmaceutical application thereof

• Main Authors: YE HAI, HU QINGJIAO, XU YE, SU LIANZHENG, JIANG SHUISHI, MIN TAO, CHEN CHEN, CAO WEI
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an alkali addition salt of a compound represented by a formula I, a crystal form of the salt, a preparation method, a pharmaceutical composition containing the salt, a preparation form and pharmaceutical application. According to the invention, the compound represented by the formula I is a pharmaceutically active substance belonging to aryl propionic acids, a novel salt form and a crystal form thereof are prepared on the basis of the compound, and the water solubility, the dissolution rate and the stability of the compound in the formula I are better than those of the compound represented by the formula I; the salt form and the crystal form thereof have the advantages of small administration dosage, quick drug effect, reduction of toxic and side effects, improvementof bioavailability and the like; and the pharmaceutical composition containing the alkali addition salt of the compound represented by the formula I has wide application and broad prospects in preparation of analgesic, antip