PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER

• Main Authors: MOOKHTIAR KASIM, MERU ASHWIN, BASU SUJAY, BASU SUJAYBASU
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure discloses a pharmaceutical composition comprising compound of Formula I, Formula II, Formula III, Formula IV, and their pharmaceutically acceptable salts, analogs, tautomeric forms, stereoisomers, geometrical isomers, polymorphs, hydrates, solvates, metabolites, and prodrugs thereof, for the manufacture of a medicament for the treatment of a condition or disorder amelioratedby inhibition of the A2A/A2B receptor. It further discloses the use of the pharmaceutical composition of the present disclosure, for the preparation of a medicament for the treatment of a condition or disorder selected from prostate cancer, rectal cancer, renal cancer, ovarian cancer, endometrial cancer, thyroid cancer, pancreatic cancer, breast cancer, colon cancer, bladder cancer, brain cancer,glial cancer, melanoma cancer, pineal gland cancer, or lung cancer. 本公开内容公开了包含式I、式II、式III、式IV化合物及其可药用盐、类似物、互变异构形式、立体异构体、几何异构体、多晶型物、水合物、溶剂合物、代谢物及其前药的药物组合物，其用于制备用来治疗通过抑制A2A/A2B受体而改善的病症或障碍的药物。本公开内容还公开了本公开内容的药物组合物用于制备用于治疗选自以下的病症或