Synthesis process of omarigliptin

The invention discloses a method for preparing omarigliptin and a method for preparing an intermediate. In the method for preparing the key intermediate compound 4 of the omarigliptin, a weak acid with the pKa value of 3.5-5 is added, so that the generation of byproducts is effectively inhibited, th...

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Bibliographic Details
Main Authors ZHONG QINGLIN, TANG XIAOLIN
Format Patent
LanguageChinese
English
Published 20.10.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for preparing omarigliptin and a method for preparing an intermediate. In the method for preparing the key intermediate compound 4 of the omarigliptin, a weak acid with the pKa value of 3.5-5 is added, so that the generation of byproducts is effectively inhibited, the yield of the intermediate compound 4 is very high, and finally, the yield of the omarigliptin is greatly improved. 本发明公开一种制备奥格列汀及中间体的方法。在制备奥格列汀关键中间体化合物4的方法中，加入pKa值为3.5～5之间的弱酸，有效抑制副产物的产生，使中间体化合物4的产率非常高，最终大大提高了奥格列汀的收率。
Bibliography:Application Number: CN202010644218