INTERLEUKIN-15 ACTIVITY ANTAGONIST PEPTIDE

• Main Authors: RODRIGUEZ ALVAREZ YUNIER, GARAY PEREZ HILDA ELISA, REYES ACOSTA OSVALDO, CABRALES RICO ANIA
• Format: Patent
• Language: Chinese; English
• Published: 16.10.2020
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present invention relates to a peptide that is an interleukin-15 (IL-15) activity antagonist and is characterized in that it comprises an amino acid sequence of SEQ ID No. 5 or SEQ ID No. 12, or to a homodimer of these peptides, and to a nucleic acid that encodes the peptide with the sequence of SEQ ID No. 5 or SEQ ID No. 12. The pharmaceutical compositions that comprise these peptides or thenucleic acids that encode these sequences are part of the invention. Moreover, the invention includes the use of an IL-15 antagonist peptide comprising the amino acid sequence of SEQ ID No. 5 or SEQ ID No. 12 or a homodimer of these peptides to prepare a medicinal drug. The invention also relates to a method for the treatment of a disease associated with IL-15 overexpression, prostate and kidney cancer. 本发明披露了其特征在于包含标识为SEQ ID No.5或SEQ ID No.12的氨基酸序列的白介素-15(IL-15)活性的拮抗剂肽，或者这些肽的同二聚体，以及编码具有标识为SEQ ID No.5或SEQ ID No.12的序列的肽的核酸。包含所述肽或编码所述序列的核酸的药用组合物是本发明的一部分。此外，本发明提供了包含标识为SEQ ID No.5或SEQ ID No.12的氨基酸序列的IL-15的拮抗剂肽或者这些肽的同二聚体在制