Application of dendrobe extract in preparation of medicine for regulating cholesterol metabolism

• Main Authors: LIANG YINGQUAN, CHEN YUANLI, YU MAOYUN, HAN JIHONG, CHEN GUILAN, ZHANG FENG, DUAN YAJUN, YANG XIAOXIAO
• Format: Patent
• Language: Chinese; English
• Published: 13.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of pharmacy, and relates to application of a dendrobe extract in preparation of a medicine for regulating cholesterol metabolism. Specifically, the invention relates to regulation of cholesterol metabolism by a dry dendrobium water extract, a fresh dendrobium water extract and a dendrobium alcohol extract in a hyperlipidemia state. In-vitro experimentsprove that the dry dendrobium water extract, the fresh dendrobium water extract and the dendrobium alcohol extract prepared by the invention can increase the atherosclerotic scavenger receptor B typeI and proprotein convertase subtilisin/kexin9 type in HUH7 cells and gene expression of the low-density lipoprotein receptor and lecithin cholesterol ester acyltransferase, so that a conclusion that the dendrobe extract can be used as a medicine for regulating cholesterol metabolism can be obtained. 本发明属制药技术领域，涉及石斛提取物在制备调节胆固醇代谢药物中的应用。具体涉及干石斛水提取物、鲜石斛水提取物和石斛醇提取物在高血脂的状态下对胆固醇代谢的调节。体外实验证明本发明制备的干石斛水提取物、鲜石斛水提取物和石斛醇提取物均可以增加HUH7细胞中