Corannulene-incorporated AIE nanodots with highly suppressed nonradiative decay for boosted cancer phototheranostics in vivo

• Main Authors: TANG BENZHONG, GU XINGGUI
• Format: Patent
• Language: Chinese; English
• Published: 02.10.2020
• Subjects: ADHESIVES; CHEMISTRY; DYES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; PAINTS; POLISHES

The present subject matter relates to fluorescent compounds that have aggregation-induced emission (AIE) characteristics and exhibit near infrared absorption. Compositions including the present compounds can include a corannulene-modified polyethylene glycol encapsulation matrix. The compositions can be in nanoparticle form. Encapsulating the AIE compounds within a corannulene matrix provides intraparticle rigidity and restricts intramolecular rotation of the encapsulated AIE compound, which results in enhanced fluorescence and ROS generation capacity of the compositions in vivo. Accordingly,the compositions can be useful in NIR imaging-guided cancer surgery and photodynamic cancer therapy. 本发明主题涉及具有聚集诱导发光(AIE)性质并表现出近红外吸收的荧光化合物。包括本发明化合物的组合物可包括碗烯改性的聚乙二醇封装基质。该组合物可以是纳米粒子形式。将AIE化合物封装在碗烯基质中提供了粒子内刚性并限制了被封装AIE化合物的分子内转动，这导致该组合物在体内荧光和ROS生成能力增强。因此，该组合物可用于NIR成像引导的癌症手术和光动力癌症治疗。