PHARMACEUTICAL COMPOSITION COMPRISING AN APL PEPTIDE

• Main Authors: DOMINGUEZ HORTA MARIA DEL CARMEN, BESADA PEREZ VLADIMIR ARMANDO, GONZALEZ LOPEZ LUIS JAVIER, LOPEZ ABAD CRUZ MATILDE
• Format: Patent
• Language: Chinese; English
• Published: 02.10.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a pharmaceutical composition comprising the APL peptide of SEQ ID No. 1, the sodium acetate buffer with a pH of 3.9-4.7, and at least one stabilising sugar selected from saccharose and trehalose. This pharmaceutical composition is useful for the treatment of inflammatory diseases associated with an increase of neutrophils or protein citrullination. These inflammatory diseases include rheumatoid arthritis (RA), juvenile chronic arthritis (JCA), ankylosing spondylitis (AS), Alzheimer's disease and hepatic or pulmonary fibrosis. The invention also relates to a method forthe treatment of these diseases by administration of a therapeutically effective dose of the pharmaceutical composition of the APL peptide of SEQ ID No. 1. 本发明提供了药用组合物，其包含标识为SEQ ID No.1的APL型肽、pH 3.9-4.7的乙酸钠缓冲液和至少一种选自蔗糖和海藻糖的稳定化糖。所述药用组合物可用于治疗与嗜中性粒细胞或蛋白质瓜氨酸化增加相关的炎性疾病。在这些炎性疾病之中包括类风湿性关节炎(RA)、幼年特发性关节炎(JIA)、强直性脊椎炎(AS)、阿尔茨海默病和肝或肺纤维化。本发明还公开了用于通过施用治疗有效量的标识为SEQ ID No.1的APL型肽的药用组合物来治疗所述疾病的方法。