Magnetic acoustic contrast agent composition, magnetic acoustic contrast agent, magnetic microvesicle acoustic contrast agent and preparation method of magnetic acoustic contrast agent

• Main Authors: DONG FEIHONG, HUANG SHUO, GUO WENYU, ZHANG JUE
• Format: Patent
• Language: Chinese; English
• Published: 02.10.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of biomedicines, in particular to a magnetic acoustic contrast agent composition, a magnetic acoustic contrast agent, a magnetic microvesicle acoustic contrast agentand a preparation method of the magnetic acoustic contrast agent. The magnetic acoustic contrast agent composition comprises lipid, a surfactant and magnetic nanometer particles, wherein the surfactant consists of a surfactant A and a surfactant B; the surfactant A is in the free state, the surfactant B is in combined state to be modified on the surfaces of the magnetic nanometer particles; and the HLB value of the surfactant A is 8. Compared with the lipid of 1mol, the content of the surfactant A is 0.1-1mol, the content of the surfactant B is 0.1-1mol, and the content of the magnetic nanometer particles is 0.05-0.5mol. The magnetic microvesicle acoustic contrast agent prepared from the magnetic acoustic contrast agent composition has high stability, can meet in vivo circulation targeting delivery requirements,