Crystal forms, preparation method and application of deuterated Palbociclib compound

• Main Authors: LI JUN, LIANG APENG, WU YUSHENG, NIU CHENGSHAN
• Format: Patent
• Language: Chinese; English
• Published: 29.09.2020
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of medicines, and particularly discloses several crystal forms of a deuterated Palbociclib compound as well as respective preparation methods and medicinalapplication of the crystal forms. The provided crystal form A is a stable crystal form compared with other crystal forms through normal temperature and accelerated stability research in combination with hygroscopicity research results. The crystal form A is used as a dominant drug crystal form, and can be further used for subsequent pharmacokinetic experiments and zoology experiment researches. 本发明属于医药技术领域，具体公开了氘代Palbociclib化合物的几种晶型、各自的制备方法以及药物用途。通过常温与加速稳定性研究，结合引湿性研究结果，本发明提供的晶型A相比其他晶型为稳定的晶型。晶型A作为优势药物晶型，可进一步进行后续药物代谢动力学实验与动物学实验研究。