Application of compound regulator in regulating metabolic disorders caused by infection of artemisinin-sensitive/ resistant Plasmodium

• Main Authors: XU LI, LIU LIANG, XU ZHENGXIN, JIA XIAOQIN, YAO YING, ZHAO XUESONG, CHEN JING
• Format: Patent
• Language: Chinese; English
• Published: 29.09.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of a compound regulator in regulating metabolic disorders caused by infection of artemisinin-sensitive/ resistant Plasmodium, and particularly relates to artemisinin and euphorbia lunulata flavone which is prepared by enriching polymethoxylated flavone from an acetone layer of an artemisinin industrial extraction waste material, and is compounded according to anoptimal antimalarial ratio of 1: 2. The compound regulator is used for improving the metabolic disorders caused by the infection of the artemisinin-sensitive/ resistant Plasmodium, and the Plasmodiumis Plasmodium berghei. According to the application, the artemisinin-resistant Plasmodium is specifically killed by the euphorbia lunulata flavone, so that a potential artemisinin drug-resistant small-molecule inhibitor is provided for clinical application; furthermore, the artemisinin-resistant small-molecule inhibitor is compounded with the artemisinin, so that the regulator for effectively improving the metabolic disor