Method for synthesizing 5-nitrosalicylaldehyde

• Main Authors: ZHANG WENWEN, YE AIYING, GONG BINGQIAN, YANG LIPING
• Format: Patent
• Language: Chinese; English
• Published: 22.09.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for synthesizing 5-nitrosalicylaldehyde. 5-nitrosalicylaldehyde is prepared by taking p-nitrophenol as a raw material and trifluoroacetic acid as a catalyst through animproved Duff reaction and hexamethylenetetramine reaction. Compared with a salicylaldehyde nitration method, the synthesis method provided by the invention effectively inhibits the generation of isomers in the synthesis process of 5-nitrosalicylaldehyde, and is convenient for separation and purification of a target product; the use of reaction raw materials with high toxicity and serious environmental pollution and high-temperature and high-pressure reaction conditions are avoided, the reaction conditions are mild, the post-treatment process is simple, the synthesis reaction efficiency is improved, and the yield of the 5-nitrosalicylaldehyde reaches 63% or above. 本发明公开了一种合成5-硝基水杨醛的方法，5-硝基水杨醛是以对硝基苯酚为原料、三氟乙酸为催化剂，经改进达夫反应与六亚甲基四胺反应制得。该发明合成方法与水杨醛硝化法相比，有效抑制了5-硝基水杨醛合成过程中异构体的产生，便于目标产物的分离提纯；避免使用毒性大、环境污染严重的反应原料以及高温高压的反应条件，