C5A RECEPTOR MODULATORS

• Main Authors: RENNEBERG DORTE, MURPHY MARK, HUBLER FRANCIS, FROIDEVAUX SYLVIE, STAMM SIMON
• Format: Patent
• Language: Chinese; English
• Published: 18.09.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to derivatives of formula (I) Formula (I) wherein Ring A, W, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators. 本发明涉及式(I)的衍生物，式(I)其中环A、W、X、Y、Z、R、R、R和R如说明书中所述，其制备，其药学上可接受的盐，以及其作为药物的用途，包含一种或多种式(I)化合物的药物组合物，以及尤其是用作C5a受体调节剂的用途。