Improved nucleotide sequences encoding peptide linkers

• Main Authors: STANSSENS PATRICK, DE BOCK PIETER-JAN, DE BRABANDERE VERONIQUE, MERCHIERS TOM, BRIGE ANN, DE FOUGEROLLES ANTONIN
• Format: Patent
• Language: Chinese; English
• Published: 11.09.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention provides improved nucleotide sequences and nucleic acids that encode glycine serine linkers and that use an excess of GGA, GGG, and GGT/GGU codons to encode the glycine residues. The invention further relates to nucleotide sequences and nucleic acids that encode (fusion) proteins and polypeptides comprising glycine serine linkers, which nucleotide sequences and nucleic acids comprisesuch improved nucleotide sequences and nucleic acids of the invention. 本发明提供编码甘氨酸丝氨酸接头且使用过量GGA、GGG及GGT/GGU密码子以编码所述甘氨酸残基之经改良的核苷酸序列及核酸。本发明进一步涉及编码包含甘氨酸丝氨酸接头的(融合)蛋白质及多肽之核苷酸序列及核酸，所述核苷酸序列及核酸包含本发明此类经改良之核苷酸序列及核酸。