Method for preparing disubstituted olefin through hydroarylation of terminal alkyne

• Main Authors: LI TING, HU JIEDONG, YANG YUHAN, LI BO
• Format: Patent
• Language: Chinese; English
• Published: 04.09.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for preparing disubstituted olefin through hydroarylation of terminal alkyne. The method comprises the following steps: mixing terminal alkyne, 2-naphthol, a catalystL1AuCl, NaBARF and a solvent in a reaction bottle, carrying out a stirring reaction for 2-4 h at a temperature of 15-25 DEG C, and after the reaction is finished, carrying out reduced-pressure concentration and purification to obtain the disubstituted olefin. The method has the advantages of mild reaction conditions, high product yield and high product purity, and the terminal alkyne can toleratea plurality of functional groups and has good reaction universality. 本发明公开了一种端基炔烃氢芳基化制备二取代烯烃的方法，包括如下步骤：将端基炔烃、2-萘酚、催化剂L1AuCl、NaBARF、和溶剂混合于反应瓶中，在15-25℃条件下搅拌反应2-4h，反应结束后，减压浓缩，纯化，得到二取代烯烃。本发明反应条件温和，产物收率高，纯度高，端基炔烃可耐受诸多官能团，反应普适性好。