Action mechanism

The invention relates to an action mechanism, and belongs to the field of TNF signal transduction. Compounds that are capable of modulating signaling of TNF trimers through receptors have been identified. Methods of identifying such compounds are thus provided. These compounds themselves have effica...

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Bibliographic Details
Main Authors WARRELLOW GRAHAM JOHN, O'CONNELL JAMES PHILIP, PORTER JOHN ROBERT, MCMILLAN DAVID JAMES, BROOKINGS DANIEL CHRISTOPHER, RAPECKI STEPHEN EDWARD, NORMAN TIMOTHY JOHN, ALEXANDER RIKKI PETER, LAWSON ALASTAIR, KROEPLIEN BORIS
Format Patent
LanguageChinese
English
Published 25.08.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to an action mechanism, and belongs to the field of TNF signal transduction. Compounds that are capable of modulating signaling of TNF trimers through receptors have been identified. Methods of identifying such compounds are thus provided. These compounds themselves have efficacy in therapy. 本发明涉及作用机制，属于TNF信号传导领域。已经鉴定出能够调节TNF三聚体通过受体的信号传导的化合物。因此提供了鉴定这种化合物的方法。这些化合物本身在治疗中具有效用。
Bibliography:Application Number: CN202010405385