Serum protein marker for diagnosing depression and application thereof

• Main Authors: CHEN SUZHEN, YUAN YONGGUI
• Format: Patent
• Language: Chinese; English
• Published: 18.08.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a serum protein marker. The marker is one or more of BDNF, cortisol and/or IFN-gamma protein. The invention also discloses application of the reagent of the serum protein marker in preparation of a mental disease diagnosis product. The invention also discloses an enzyme-linked immunosorbent assay kit. When the three proteins are used together to distinguish MDD and HC, AUCunder an ROC curve is 0.884, the sensitivity and specificity are 86.7% and 83.3% respectively, and the kit has a very good MDD diagnosis value; when only BDNF and cortisol are used in a combined modeto distinguish MDD and HC, AUC is 0.841, specificity is 66.7%, but sensitivity is as high as 90%, and therefore the marker has a good MDD screening value. 本发明公开了一种血清蛋白标志物，所述标志物为BDNF、皮质醇和/或IFN-gamma蛋白中的一种或几种。本发明还公开了所述的血清蛋白标志物的试剂在制备精神疾病诊断产品中的应用。本发明还公开了一种酶联免疫吸附测定试剂盒。本发明联合使用上述三种蛋白区分MDD和HC时ROC曲线下的AUC为0.884，敏感性和特异性分别为86.7%和83.3%，具有很好的MDD诊断价值；而当仅联合使用BDNF和皮质醇区分MDD和HC时AUC为0.841，特异性为66.7%，但敏感性高达90%，因而具有很好的MDD筛查价值。