Tumor microenvironment responsive surface charge reversible nano-drug delivery carrier

The invention discloses a tumor microenvironment responsive surface charge reversible nano-drug delivery carrier which can be applied to specific detection and efficient treatment of MMP9 high-expression tumors. The functional amphiphilic molecular structure consists of three parts: oleic acid is a...

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Bibliographic Details
Main Authors ZHANG QIANGZHE, HAN QIUJU, LI LUYUAN
Format Patent
LanguageChinese
English
Published 07.08.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NANOTECHNOLOGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
TRANSPORTING
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Summary:The invention discloses a tumor microenvironment responsive surface charge reversible nano-drug delivery carrier which can be applied to specific detection and efficient treatment of MMP9 high-expression tumors. The functional amphiphilic molecular structure consists of three parts: oleic acid is a hydrophobic region of the molecule, the middle connecting part is MMP9 responsive broken polypeptide, and the other part is a polypeptide fragment rich in glutamic acid, so that a negatively charged amphiphilic molecule is formed. According to the nano delivery carrier, a basic framework with positive charges is composed of (2,3-Dioleoyloxy-propyl)-trimethylammonium-chloride, 1, 2-dioleoyl-sn-glycero-3-phosphocholine, soybean lecithin, DSPE-PEG2000; and after the basic framework is modified by functional amphiphilic molecules OMPE, surface charges are reversed into negative charges. Cell and animal experiments show that the nano delivery carrier can effectively deliver a detection probe anda tumor drug, and has ver
Bibliography:Application Number: CN202010323590