Temperature-sensitive non-isocyanate polyurethane as well as preparation method and application thereof

• Main Authors: ZHOU JUYING, XIA XUE, ZHAO YANZHI, XU HAITANG
• Format: Patent
• Language: Chinese; English
• Published: 04.08.2020
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention discloses temperature-sensitive non-isocyanate polyurethane as well as a preparation method and an application thereof, the non-isocyanate polyurethane is prepared by reaction of soybeanoil cyclic carbonate and methoxy polyethylene glycol amine, and can replace traditional polyurethane to be applied to biomedical materials. When the non-isocyanate polyurethane is used for preparinga nano-micelle carrier, the nano-micelle carrier does not have residues of highly toxic isocyanate, and has good biodegradability, blood compatibility and a good slow-release effect. The preparation method can be applied to medicinal sustained-release materials. 本发明公开了一种温敏性非异氰酸酯聚氨酯及其制备方法和应用，该非异氰酸酯聚氨酯通过大豆油环碳酸酯与甲氧基聚乙二醇胺反应制备得到，可替代传统聚氨酯应用在生物医用材料。利用本发明非异氰酸酯聚氨酯制备纳米胶束载体，该纳米胶束载体没有剧毒异氰酸酯的残留，具有良好的生物降解性和血液相容性和较好的缓释效果。可以应用于药用缓释材料。