Blood-brain barrier permeability regulating agent and application thereof

• Main Authors: WANG KAI, HU FUQIANG, MENG TINGTING, YUAN HONG, WEN LIJUAN
• Format: Patent
• Language: Chinese; English
• Published: 04.08.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to application of SC79 or analogues thereof in preparation of a blood-brain barrier permeability regulating agent. The blood-brain barrier permeability regulating agent takes SC79 or an analogue thereof as an effective component; by activating Claudin-5 and Occludin signal paths at the downstream of the protein kinase B, the expression of the closely linked proteins Claudin-5and Occludin is reduced, and the expression of the Occludin is reduced. Therefore, the blood-brain barrier permeability is improved, the brain-entering transport efficiency of the brain-targeted drugdelivery system is enhanced, and especially, the brain-entering transport efficiency of the Angiopep-2 modified glycolipid nano-drug delivery system can be enhanced. The invention also relates to a kit, which comprises the blood-brain barrier permeability regulating agent and a brain-targeted drug delivery system. According to the invention, the blood-brain barrier permeability regulating agent and the brain-targeted drug