MULTI-PARAMETER METABOLIC VULNERABILITY INDEX EVALUATIONS

• Main Authors: OTVOS JAMES D, SHALAUROVA IRINA Y
• Format: Patent
• Language: Chinese; English
• Published: 24.07.2020
• Subjects: DIAGNOSIS; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; SURGERY; TESTING

Disclosed are methods and systems to determine a subject's metabolic vulnerability index (MVX) score using at least one defined mathematical model of risk. The methods comprise evaluating various biomarkers to distinguish various health risks. In one embodiment, the method comprises evaluating biomarkers to determine a relative risk of premature all-cause mortality. The model may include NMR-derived measurements of GlycA, S-HDLP, branched chain amino acids (BCAAs), ketone bodies, total serum protein, and citrate in at least one biosample of the subject. 公开了使用至少一种规定的风险数学模型来确定受试者的代谢脆弱性指数(MVX)分数的方法和系统。所述方法包括评估各种生物标志物以区分各种健康风险。在一个实施方案中，所述方法包括评估生物标志物以确定过早全因死亡的相对风险。所述模型可包括所述受试者的至少一种生物样品中GlycA、S-HDLP、支链氨基酸(BCAA)、酮体、总血清蛋白和枸橼酸盐的NMR导出的测量结果。