ANTI-ANGIOGENIC ADENOVIRUS

• Main Authors: LARSON CHRISTOPHER, ORONSKY BRYAN T, REID TONY R
• Format: Patent
• Language: Chinese; English
• Published: 24.07.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to a recombinant adenovirus that expresses endostatin, angiostatin, or a combination of endostatin and angiostatin. The invention also relates to method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of a combination of (i) a recombinant adenovirus and (ii) an anti-angiogenic agent to treat the cancer inthe subject. 本发明涉及表达内皮抑素、血管抑素、或内皮抑素和血管抑素的组合的重组腺病毒。本发明还涉及治疗需要的受试者癌症的方法，所述方法包含向受试者施用有效量的(i)重组腺病毒和(ii)抗血管生成剂的组合以治疗受试者的癌症。