Irinotecan hydrochloride medicine and aspirin common-carried liposome, and preparation method and application thereof

• Main Authors: WANG YITING, FANG XIAOYAN, WANG JING, YAN ZHIQIANG, LUO SHENGGEN, YU LEI, DUAN YANHONG
• Format: Patent
• Language: Chinese; English
• Published: 24.07.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an irinotecan hydrochloride medicine and aspirin common-carried liposome. The irinotecan hydrochloride medicine and aspirin common-carried liposome is mainly prepared from irinotecan hydrochloride medicines, aspirin and lipid as raw materials, wherein the irinotecan hydrochloride medicines are irinotecan alkali or irinotecan hydrochloride. The invention further provides a preparation method and application of the irinotecan hydrochloride medicine and aspirin common-carried liposome. The irinotecan hydrochloride medicine and aspirin common-carried liposome has the following technical effects that the irinotecan medicines and the aspirin are jointly entrapped in liposome, the prepared common-carried liposome has notable antitumous effects, and the irinotecan and the aspirin can be jointly delivered into tumors, so that the release of the irinotecan and the aspirin at the tumors can be increased, and the antitumor effect can be strengthened. 本发明提供了一种伊利替康类药物与阿司匹林共载脂质体，主要由伊利替康类药物、阿司匹林和脂类物质为原