(S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole TRPV1 antagonists as well as preparation and application thereof
The invention discloses (S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole novel TRPV1 antagonists as well as a preparation method and application thereof, and particularly relates to compounds represented bya general formula (I) or a general formula (II) and a pharmaceutically acceptable salt thereof. The...
Saved in:
Main Authors | , , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
17.07.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention discloses (S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole novel TRPV1 antagonists as well as a preparation method and application thereof, and particularly relates to compounds represented bya general formula (I) or a general formula (II) and a pharmaceutically acceptable salt thereof. The compound have a strong analgesic effect, the activity of part of the compounds is far higher than that of a TRPV1 receptor antagonist BCTC, almost no body temperature rise side effect exists, and the invention further relates to a preparation method of the compounds and pharmaceutical preparationscontaining the compounds.
本发明公开了一种-4/5-苯基-2-(吡咯烷-2-基)噻唑类新型TRPV1拮抗剂及其制备方法和应用,尤其涉及通式(Ⅰ)或通式(Ⅱ)中化合物及其药学上可接受的盐。这类化合物具有较强的镇痛作用,部分化合物活性远高于TRPV1受体拮抗剂BCTC,并且几乎无体温升高副作用,本发明还涉及该类化合物的制备方法及含有它们的药物制剂。 |
---|---|
Bibliography: | Application Number: CN202010392794 |