(S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole TRPV1 antagonists as well as preparation and application thereof

The invention discloses (S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole novel TRPV1 antagonists as well as a preparation method and application thereof, and particularly relates to compounds represented bya general formula (I) or a general formula (II) and a pharmaceutically acceptable salt thereof. The...

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Bibliographic Details
Main Authors GAO MENGKANG, QIAO ZHENRUI, HU JING, YAN LIN, WANG YUSUI, QIAO YUE
Format Patent
LanguageChinese
English
Published 17.07.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses (S)-4/5-phenyl-2-(pyrrolidin-2-yl)thiazole novel TRPV1 antagonists as well as a preparation method and application thereof, and particularly relates to compounds represented bya general formula (I) or a general formula (II) and a pharmaceutically acceptable salt thereof. The compound have a strong analgesic effect, the activity of part of the compounds is far higher than that of a TRPV1 receptor antagonist BCTC, almost no body temperature rise side effect exists, and the invention further relates to a preparation method of the compounds and pharmaceutical preparationscontaining the compounds. 本发明公开了一种-4/5-苯基-2-(吡咯烷-2-基)噻唑类新型TRPV1拮抗剂及其制备方法和应用，尤其涉及通式（Ⅰ）或通式（Ⅱ）中化合物及其药学上可接受的盐。这类化合物具有较强的镇痛作用，部分化合物活性远高于TRPV1受体拮抗剂BCTC，并且几乎无体温升高副作用，本发明还涉及该类化合物的制备方法及含有它们的药物制剂。
Bibliography:Application Number: CN202010392794