Alpha-aminoacrylic acid microbicide, and preparation method and application thereof

• Main Authors: HAN CENHUI, YU BIN, YANG HUAIPU, WU AOBEN, FAN ZHIJIN, QIAN XIAOLIN, MA LIUYONG, JIN JIANYU, XUE JING, WANG HAIXIA, ZHANG NAILOU, WU QIFAN
• Format: Patent
• Language: Chinese; English
• Published: 03.07.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The invention provides an alpha-aminoacrylic acid microbicide, and a preparation method and an application thereof. The alpha-aminoacrylic acid microbicide specifically has a chemical structural general formula as shown in a formula I which is described in the specification. According to the invention, by utilization of the principle of pesticide molecule design, a lead compound with medical anti-coronavirus activity is subjected to structural modification of agricultural plant virus resistant activity; a series of alpha-aminoacrylic acid derivatives are designed and synthesized; specifically,a piperidine ring-containing alpha-aminoacrylic acid derivative is mainly synthesized; a known compound is used as a positive control compound for systematic biological activity screening; a plurality of highly-efficient antiviral lead molecules are provided for creation of novel pesticides; and positive significance in pesticide reduction application and environmental ecological protection is achieved. 本发明提供了一种α-氨基丙烯酸类杀