Naproxen zinc complex with antibacterial activity and preparation method thereof

• Main Authors: GE XIANGYU, ZHU HAILIANG, CHU YICHUN, LUO QINGYANG, JIA RU, WANG TIANTIAN
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2020
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a naproxen zinc complex with antibacterial activity and a preparation method thereof, and belongs to the technical fields of complex synthesis and medicinal chemistry. According to the invention, naproxen and 1,3-propane diamine are respectively used as a main ligand and a second ligand, zinc ions are used as central ions, and a solvent evaporation method is utilized to prepare the naproxen zinc complex with a mononuclear structure. It is found through detection that the MIC values of the complex, naproxen and a positive control drug ciprofloxacin about the minimal inhibitory concentration of staphylococcus aureus are 56.25 [mu]g/mL, larger than 225 [mu]g/mL and 1.76 [mu]g/mL respectively, and therefore it is shown that the antibacterial activity of the complex is superior to that of naproxen and the complex has certain antibacterial activity. 本发明公开了一种具有抗菌活性的萘普生锌配合物及其制备方法，属于配合物合成及药物化学技术领域。本发明分别以萘普生和1，3-丙二胺为主配体和第二配体，以锌离子为中心离子，利用溶剂挥发法，制备出单核结构的萘普生锌配合物。经检测发现，本发明所述配合物、萘普生及阳性对照药环丙沙星对金黄色葡萄球菌关