Synthesis of a macrocyclic HCV NS3 inhibiting tripeptide

• Main Authors: WALTMAN ANDREW W, COLBY DENISE A, CHAN JOHANN, KEATON KATIE ANN, SENG PAMELA, SHAPIRO NATHAN, REYNOLDS TROY, TAYLOR JAMES G, KONDAPALLY SUDHA, CAGULADA AMY, LEVINS CHRIS, CHAN LINA, PCION DOMINIKA, KATO DARRYL, ROSS BRUCE, YU LAWRENCE, SIEGEL DUSTIN, TRIPP JONATHAN, MARTINEZ RUBEN, TANG DONALD, LITTKE ADAM, SANGI MICHAEL, KARKI KAPIL KUMAR, SCHRIER ADAM J
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The invention relates to synthesis of a macrocyclic HCV NS3 inhibiting tripeptide. The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I. 本发明涉及大环HCV NS3抑制三肽的合成。本公开提供用于制备可用作抗病毒剂的式I的化合物的方法。本公开还提供作为式I化合物的合成中间体的化合物和用于制备该化合物的方法。