Anti-CD8 antibodies and uses thereof
Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. A...
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Main Authors | , , , , |
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Format | Patent |
Language | Chinese English |
Published |
16.06.2020
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Abstract | Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of usingsuch anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.
提供的是结合人CD8且并不刺激或抑制CD8T细胞激活的抗CD8抗体。还提供的是编码此类抗CD8抗体的核酸,包含此类核酸的载体,包含其的宿主细胞,和生成此类抗CD8抗体的方法。还提供的是与可检测标记物缀合的抗CD8抗体。提供的是在受试者中使用此类抗CD8抗体来检测CD8T细胞,在具有癌症的受试者中监测疾病进展,和在具有癌症的受试者中监测治疗进展的方法。 |
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AbstractList | Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of usingsuch anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.
提供的是结合人CD8且并不刺激或抑制CD8T细胞激活的抗CD8抗体。还提供的是编码此类抗CD8抗体的核酸,包含此类核酸的载体,包含其的宿主细胞,和生成此类抗CD8抗体的方法。还提供的是与可检测标记物缀合的抗CD8抗体。提供的是在受试者中使用此类抗CD8抗体来检测CD8T细胞,在具有癌症的受试者中监测疾病进展,和在具有癌症的受试者中监测治疗进展的方法。 |
Author | CHEN YVONNE M WILLIAMS SIMON-PETER ALBERT MATTHEW LAWRENCE GROGAN JANE LOUISE CHIANG EUGENE YUUAN |
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DocumentTitleAlternate | 抗CD8抗体及其用途 |
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Snippet | Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding... |
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Title | Anti-CD8 antibodies and uses thereof |
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