Anti-CD8 antibodies and uses thereof

• Main Authors: ALBERT MATTHEW LAWRENCE, CHEN YVONNE M, WILLIAMS SIMON-PETER, CHIANG EUGENE YUUAN, GROGAN JANE LOUISE
• Format: Patent
• Language: Chinese; English
• Published: 16.06.2020
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8+ T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of usingsuch anti-CD8 antibodies to detect CD8+ T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer. 提供的是结合人CD8且并不刺激或抑制CD8T细胞激活的抗CD8抗体。还提供的是编码此类抗CD8抗体的核酸,包含此类核酸的载体,包含其的宿主细胞,和生成此类抗CD8抗体的方法。还提供的是与可检测标记物缀合的抗CD8抗体。提供的是在受试者中使用此类抗CD8抗体来检测CD8T细胞,在具有癌症的受试者中监测疾病进展,和在具有癌症的受试者中监测治疗进展的方法。