CARTILAGE REGENERATION COMPOSITION CONTAINING HAPLN1 AS ACTIVE INGREDIENT

• Main Authors: KIM DAE-KYONG, JANG JI-MIN
• Format: Patent
• Language: Chinese; English
• Published: 16.06.2020
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a cartilage regeneration composition containing HAPLN1 as an active ingredient, and according to the present invention, HAPLN1 protein can stimulate cartilage formation and joint cartilage regeneration, and can increase the expression level of TGF-beta receptor I of cartilage cells to increase the component ratio of cells that can form cartilage and induce regeneration of cartilaginous tissue. Therefore, HAPLN1 protein according to the present invention is a novel composition for controlling TGF-beta signal transmission and can be effectively used as a pharmaceutical composition, health food, and a reagent composition for cartilage regeneration. 本发明涉及一种包括HAPLN1作为有效成分的用于软骨再生的组合物，根据本发明，HAPLN1蛋白具有促进软骨形成和关节软骨再生的能力，可以通过提高软骨细胞中TGF-β受体I的表达水平来增加具有软骨形成能力的细胞的组成比并诱导软骨组织再生。因此，本发明的HAPLN1蛋白作为用于调节TGF-β信号传导的新型组合物，可有效地用作用于软骨再生的药物组合物、用于软骨再生的保健食品组合物或用于软骨再生的试料组合物。