Method for catalytically synthesizing high-purity 4-chloromethyl-5-methyl-1,3-dioxol-2-one

• Main Authors: CHEN ZHAO, YU FUGANG, WANG SHUJUAN, QIU HUAQI
• Format: Patent
• Language: Chinese; English
• Published: 16.06.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for catalytically synthesizing high-purity 4-chloromethyl-5-methyl-1,3-dioxol-2-one. The methodcomprises the steps: taking 4,5-dimethyl-1,3-dioxol-2-one as a raw material, taking solid alkali as a catalyst, heating and refluxing in the presence of an organic solvent, taking a chlorine dichloroethane solution as a chlorination reagent, and performing reflux reaction after dropwise adding is finished; after the reaction is finished, washing with water, layering, extracting, drying an organicphase with anhydrous magnesium sulfate, filtering, performing reflux rearrangement on filtrate for 2-4 h, and after the reaction is monitored to be finished by TLC, carrying out reduced pressure distillation, separation and nitrogen purging on the reaction liquid to obtain a 4-chloromethyl-5-methyl-1,3-dioxol-2-one crude product; and purifying to obtain the 4-chloromethyl-5-methyl-1,3-dioxol-2-one. The method has the char