Benzimidazole based on dicarboxylic acid as well as preparation and application thereof

• Main Authors: GAO QIHE, YAN LIMING
• Format: Patent
• Language: Chinese; English
• Published: 12.06.2020
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PEPTIDES; PHYSICS; POLISHES; TESTING

The invention provides benzimidazole based on dicarboxylic acid as well as preparation and application thereof. The benzimidazole based on dicarboxylic acid has a structural general formula shown in the specification, wherein R is a saturated or unsaturated carbon chain with the carbon atom number of 2-18. The benzimidazole derivative containing free aliphatic carboxyl provided by the invention provides wider application for the benzimidazole derivative based on the excellent performance of the benzimidazole parent nucleus and the safety, fat solubility and alkali solubility of the long-chaindicarboxylic acid in vivo. 本发明提出一种基于二元羧酸的苯并咪唑及其制备和应用，所述基于二元羧酸的苯并咪唑具有如下的结构通式：R为碳原子数为2～18的饱和或不饱和碳链。本发明提出的含有游离脂肪羧基的苯并咪唑衍生物，基于苯并咪唑母核的优良性能以及长链二元酸的生物体内的安全性、脂溶性和碱溶性，为苯并咪唑衍生物提供了更广阔的应用。