Preparation method of 2,4,5-trifluoro-3-methoxybenzoyl chloride and intermediate thereof

• Main Authors: FANG XIANG, WANG JUN, LU LIUCHUN, ZHANG XIANGUO, ZHANG YUHONG, WANG XIAOCHUN, ZHANG YONGCHAI
• Format: Patent
• Language: Chinese; English
• Published: 09.06.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method of 2,4,5-trifluoro-3-methoxybenzoyl chloride and intermediate thereof. The preparation method of 2,4,5-trifluoro-3-methoxybenzoyl chloride comprises the following steps: by taking tetrafluorophthalic acid as a raw material, carrying out defluorination hydroxylation and acidification decarboxylation to obtain 2,4,5-trifluoro-3-hydroxybenzoic acid, thenreacting with dimethyl carbonate to obtain 2,4,5-trifluoro-3-methoxybenzoic acid, and finally carrying out acylating chlorination to obtain 2,4,5-trifluoro-3-methoxybenzoyl chloride. The preparation process is simple, the total reaction yield is high, the product quality is good, the process route is environment-friendly, and the method has a good industrial application prospect. 本发明公开了一种2,4,5-三氟-3-甲氧基苯甲酰氯及其中间体的制备方法，该酰氯的制备方法以四氟邻苯二甲酸为原料，经脱氟羟基化、酸化脱羧反应得到2，4，5-三氟-3-羟基苯甲酸，再与碳酸二甲酯反应得到2,4,5-三氟-3-甲氧基苯甲酸，最后经酰氯化得到2,4,5-三氟-3-甲氧基苯甲酰氯。本发明的制备工艺简单，反应总收率高、产品质量好，并且工艺路线绿色环保，具有良好的工业化应用前景。