FC-GAMMA RECEPTOR MUTANTS

• Main Authors: JO MIGYEONG, JUNG SANG TAEK, KO SANGHWAN, HWANG BORA
• Format: Patent
• Language: Chinese; English
• Published: 19.05.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The present invention relates to a polypeptide comprising an Fc-[gamma] receptor mutant. The Fc-[gamma] receptor mutant of the present invention is optimized by replacing a part of an amino acid sequence of an Fc-[gamma] receptor with a different amino acid sequence, so as to have an excellent selective binding ability to immunoglobulins, thereby being effectively useful for uses of increasing thein vivo half-life of drugs, detecting and purifying immunoglobulins, and inhibiting organ transplantation reactions or preventing or treating autoimmune diseases. 本公开涉及包含Fcγ受体突变体的多肽。通过用不同的氨基酸序列置换Fcγ受体的部分氨基酸序列来优化本公开的Fcγ受体突变体，以便具有对免疫球蛋白优异的选择性结合能力，从而有效地用于延长药物的体内半衰期、检测和纯化免疫球蛋白、并抑制器官移植排斥或预防或治疗自身免疫性疾病的用途。