Curcumin symmetrical derivative, preparation thereof and application thereof in preparation of antitumor drugs

• Main Authors: LIU ZHENBAO, WEN NACHUAN, PENG DONGMING, LIU YANFEI, HOU JIAOJIAO
• Format: Patent
• Language: Chinese; English
• Published: 19.05.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of anti-cancer chemotherapy drugs, particularly discloses a curcumin symmetrical derivative with a brand-new structure, and further provides a preparation method ofthe curcumin symmetrical derivative and application of the curcumin symmetrical derivative in preparation of anti-tumor drugs. Experiments prove that the compound with the brand-new structure has extremely high loading efficiency and excellent toxicity selectivity. 本发明属于抗癌化疗药物领域，具体公开了一种全新结构的姜黄素对称衍生物，本发明还提供了所述的化合物的制备方法和在制备抗肿瘤药物中的应用。实验证明，本发明的全新结构的化合物具有极高的负载效率与优异的毒性选择性。