Application of mesenchymal cells overexpressing ACE2 to respect of preparation of medicines for treating novel coronaviruses and preparation method of mesenchymal cells

• Main Authors: CHEN GANG, GU XIAOSONG, WEI ZHONGYA, ZHAO YAYU, WANG XIAODONG
• Format: Patent
• Language: Chinese; English
• Published: 19.05.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention belongs to the technical field of medical care research, relates to medicines for treating novel coronaviruses, and discloses an application of mesenchymal cells overexpressing ACE2 to the respect of preparation of medicines for treating novel coronaviruses. The invention further discloses medicines for treating the novel coronaviruses. The medicines at least comprise mesenchymal cells overexpressing the ACE2. In addition, the invention further discloses a preparation method of the mesenchymal cells overexpressing the ACE2. The mesenchymal cells overexpressing the ACE2 are obtained by a transfection method, and plasmid carrying the ACE2 is transfected to the mesenchymal cells. When bone marrow mesenchymal cells overexpressing the ACE2 and pulmonary epithelial cell strains subjected to viral infection are co-cultured, the death of pulmonary epithelial cells can be significantly reduced; and through instilling mesenchymal cells high in expression level of the ACE2 in a trachea, lung injury caused