Method for the safe induction of immunity against RSV

• Main Authors: WILLIAMS KRISTI, SADOFF JERALD, GODEAUX OLIVIER, CALLENDRET BENOIT, WIDJOJOATMODJO MYRA
• Format: Patent
• Language: Chinese; English
• Published: 15.05.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to methods of inducing a safe immune response against respiratory syncytial virus (RSV) in a human subject in need thereof, comprising administering to the subject a composition comprising recombinant adenovirus comprising nucleic acid encoding an RSV Fusion (F) protein comprising the amino acid sequence of SEQ ID NO: 1, and a pharmaceutically acceptable carrier, in atotal dose of from about 1x1010 to about 2x10 11 viral particles (vp). 本发明涉及在有需要的人受试者中诱导针对呼吸道合胞病毒(RSV)的安全免疫应答的方法，该方法包括向受试者施用包含重组腺病毒和药学上可接受的载体的组合物，该重组腺病毒包含编码RSV融合(F)蛋白的核酸，该RSV融合(F)蛋白包含SEQ ID NO:1的氨基酸序列，该组合物的总剂量为从约1x 10至约2x 10病毒颗粒(vp)。