METHODS AND COMPOSITIONS FOR HETEROLOGOUS REPRNA IMMUNIZATIONS

Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The composit...

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Main Authors PORTER ELY BLANTON, IRVINE DARRELL J, VAN DER NEUT KOLFSCHOTEN MARIJN, MELO MARIANE BANDEIRA, KITADA TASUKU, WEISS RON, VOGELS RONALD
Format Patent
LanguageChinese
English
Published 15.05.2020
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans. 本发明涉及用于在人中针对免疫原诱导免疫应答的组合物和方法。通过给药体外转录的(IVT)自我复制型RNA(repRNA)和腺病毒载体的异源初免-加强免疫组合获得诱导的免疫应答。所述组合物和方法可用于提供针对人疾病(如病毒感染或癌症)的保护性免疫。
Bibliography:Application Number: CN201880063070