Method, system and computer program for computer-assisted evaluation of biomarkers in a tissue sample

• Main Authors: HIEMANN RICO, ELIMPORT ALEXEY, VON NEUBECK CLARE
• Format: Patent
• Language: Chinese; English
• Published: 08.05.2020
• Subjects: CALCULATING; COMPUTING; COUNTING; IMAGE DATA PROCESSING OR GENERATION, IN GENERAL; PHYSICS

Disclosed are a method for computer-assisted evaluation of biomarkers in a tissue sample as well as a corresponding system and computer program. The method comprising the following steps: providing animage of the tissue sample in which cell nuclei of the tissue as well as biomarkers are represented, automatically determining for a plurality of locations or regions within the image a blood vesselprobability that represents a probability that the image at the corresponding location or region represents a blood vessel, automatically determining an assumed blood vessel location within said imagebased on a distribution of blood vessel probability with respect to said locations or regions within the image, automatically selecting biomarkers represented in said image at locations outside the assumed blood vessel location but within a threshold distance from said assumed blood vessel location, and automatically evaluating the selected biomarkers. 公开了用于组织样品中的生物标志物的计算机-辅助评价的方法，以及相应的系统和计算机程序。该方法包括以下步骤：提供表示了组织的细胞核以及生物标志物