Method for detecting cholesterol by SiO2-sol-gel-coated CsPbBr3 quantum dots

• Main Authors: SONG MINXIA, GUAN JIE, XU QIN
• Format: Patent
• Language: Chinese; English
• Published: 08.05.2020
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING; NANOTECHNOLOGY; PERFORMING OPERATIONS; PHYSICS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TESTING; TRANSPORTING

The invention discloses a method for detecting cholesterol by SiO2-sol-gel-coated CsPbBr3 quantum dots. The method comprises the following steps: preparing MTMOS encapsulated CsPbBr3QDs with a core-shell structure by adopting a thermal injection method, and taking the MTMOS encapsulated CsPbBr3QDs as a fluorescence signal unit to prepare a molecularly imprinted fluorescence sensor MIPs/CsPbBr3@SiO2QDs. According to the sensor, TMOS is used as a cross-linking agent, APTEs are used as functional monomers and reaction with template molecules CHO is made under the action of Van der Waals' force, the linear relation between the fluorescence quenching intensity and cholesterol concentration is obtained through elution and recognition processes, the fluorescence peak value of human serum to be detected is measured, and the content of cholesterol in human serum can be calculated by substituting the fluorescence peak value into the linear relation. The detection method disclosed by the invention has the advantages of