Method for preparing deoxyelephantopin or isodeoxyelephantopin

• Main Authors: ZHU YANGCHEN, ZHAO LING
• Format: Patent
• Language: Chinese; English
• Published: 08.05.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for preparing deoxyelephantopin or isodeoxyelephantopin. According to the method provided by the invention, AB-8 macroporous resin is adopted for preliminary enrichment and HSCCC separation and purification, according to the method, deoxyelephantopin or isodeoxyelephantopin with the purity of 99.6% and 99.5% respectively can be prepared, the recovery rate reaches 1.05 g of deoxyelephantopin per 1 kg of an elephantopus scaber medicinal material and 2.38 g of isodeoxyelephantopin per 1 kg of the elephantopus scaber medicinal material respectively, the purity is high, and the recovery rate is high. 本发明公开了一种制备去氧地胆草内酯或异去氧地胆草内酯的方法。本发明提供的方法采用AB-8大孔树脂初步富集和HSCCC分离纯化，可以制备得到纯度分别为99.6％、99.5％的去氧地胆草内酯、异去氧地胆草内酯，回收率分别达1.05g去氧地胆草内酯/1kg地胆草药材、2.38g异去氧地胆草内酯/1kg地胆草药材，纯度高且回收率高。