Green synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone

• Main Authors: YUAN KAIFENG, HU XINLI, XIANG ZHANBO, XIANG ZHANFENG
• Format: Patent
• Language: Chinese; English
• Published: 08.05.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a green synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone. 2,2,6,6-tetramethylpiperidone and DMC which serve as raw materials are stirred and reacted at a certain temperature for a certain time under the actions of a solvent and a catalyst, cooling, filtering, concentrating and negative pressure rectification are carried out after the reaction is finished in order to obtain the final product 1,2,2,6,6-pentamethyl-4-piperidone, and yield can reach 90%. Toxic and harmful dimethyl sulfate, chloroform, methyl iodide, formaldehyde, formic acid and the like are not usedin the whole synthesis process, no wastewater is discharged in the production process, and the method is a green synthesis mode of 1,2,2,6,6-pentamethyl-4-piperidone. 本发明公开了一种1,2,2,6,6-五甲基-4-哌啶酮的绿色合成方法，以2,2,6,6-四甲基哌啶酮、DMC为原料，在溶剂、催化剂的作用下，在一定温度下搅拌反应一定时间，反应结束后，降温、过滤、浓缩、负压精馏得到最终产物1,2,2,6,6-五甲基-4-哌啶酮，收率可达90%；整个合成工艺过程中不使用有毒有害的硫酸二甲酯、氯仿、碘甲烷、甲醛、甲酸等，生产过程中无废水排放，是一种1,2,2,6,6-五甲基-4-哌啶酮的绿色合成方式。